Migratory effects on the body surface of Angiostrongylus cantonensis from subarachnoid space to pulmonary artery in rats.
Southeast Asian J Trop Med Public Health
;
1990 Sep; 21(3): 475-81
Artículo
en Inglés
| IMSEAR
| ID: sea-33784
ABSTRACT
Juvenile worms of Angiostrongylus cantonensis recovered from subarachnoid spaces and pulmonary arteries of rats, respectively, at 28 days post-infection have been compared with respect to their surface composition, antigenicity of surface proteins and morphological appearance. Quantitative and qualitative differences were shown between surface proteins of these two stages of worms. One major and 6 minor proteins appeared on brain stage worm's surface as assessed by surface-labelling and SDS-PAGE techniques. The same, but more predominant banding pattern, with one additional major protein of Mr 80,000 kDa presented on the lung stage worm's surface. Surface components from both stages were antigenic in permissive rat hosts but refractory in nonpermissive human hosts. The surface antigens are common to both stages within the rat. Observed by scanning electron microscopy, the surface appearance of brain stage worms is thickened, rough and irregular. Besides, particle clusters adhere randomly, without cluster adherence but transverse and longitudinal clefts were shown on the surface, before the outer layer was shed. The possible mechanisms of evasion from the host's immune attack with the surface-shedding phenomenon remain to be elucidated.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Arteria Pulmonar
/
Ratas
/
Ratas Endogámicas
/
Espacio Subaracnoideo
/
Microscopía Electrónica de Rastreo
/
Angiostrongylus
/
Animales
/
Proteínas de la Membrana
/
Meningoencefalitis
/
Antígenos Helmínticos
Tipo de estudio:
Investigación cualitativa
Idioma:
Inglés
Revista:
Southeast Asian J Trop Med Public Health
Año:
1990
Tipo del documento:
Artículo
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