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Adherence of human eosinophils to infective filariform larvae of Necator americanus in vitro.
Southeast Asian J Trop Med Public Health ; 1987 Mar; 18(1): 66-72
Artículo en Inglés | IMSEAR | ID: sea-33951
ABSTRACT
Eosinophilia is common in hookworm infection but the interaction between eosinophils and the larval stage of the parasite is poorly understood. The present study was conducted to test the ability of the eosinophils to adhere to infective filariform larvae of Necator americanus in vitro. Adherence of eosinophils to the larvae was found to be serum dependent. Antibody facilitated eosinophil adherence but this was maximal in the presence of complement. The adherence was greatly diminished by EGTA treated normal human serum (NHS) and was completely abolished when NHS was treated with either EDTA or heat-inactivation, suggesting that the process can be facilitated through complement activation via the alternative pathway. As with other nematodes, the surface of hookworm larvae appeared to be both antigenic and complement-activating. Although it is not known whether eosinophil adherence has any larvicidal effect, the present study demonstrated for the first time a definite interaction between human eosinophils and hookworm filariform larvae.
Asunto(s)
Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Humanos / Proteínas del Sistema Complemento / Anticuerpos Antihelmínticos / Adhesión Celular / Eosinófilos / Animales / Necator / Necatoriasis Idioma: Inglés Revista: Southeast Asian J Trop Med Public Health Año: 1987 Tipo del documento: Artículo

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Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Humanos / Proteínas del Sistema Complemento / Anticuerpos Antihelmínticos / Adhesión Celular / Eosinófilos / Animales / Necator / Necatoriasis Idioma: Inglés Revista: Southeast Asian J Trop Med Public Health Año: 1987 Tipo del documento: Artículo