Lack of interferon induction in man by two rabies tissue culture vaccines.
Southeast Asian J Trop Med Public Health
;
1985 Dec; 16(4): 521-4
Artículo
en Inglés
| IMSEAR
| ID: sea-34307
ABSTRACT
Both neutralising antibody and interferon play a part in protection of animals against death from rabies virus infection. Interferon induction was therefore sought in 53 volunteers within 24 hours of receiving human diploid cell strain vaccine or fetal bovine kidney cell vaccine given either intramuscularly or intradermally. Repeat observations were made in 18 subjects following a second dose of vaccine seven days later. No interferon was detected in any sample tested although no subject had any detectable rabies neutralising antibody on day 0. The sensitivity of the interferon assay, and comparison with other studies are discussed. An interferon inducer suitable for human use should be sought as an alternative to, or a replacement for, passive rabies immunization.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Humanos
/
Masculino
/
Vacunas Antirrábicas
/
Adolescente
/
Interferones
/
Inmunización
/
Adulto
/
Persona de Mediana Edad
/
Anticuerpos Antivirales
Idioma:
Inglés
Revista:
Southeast Asian J Trop Med Public Health
Año:
1985
Tipo del documento:
Artículo
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