Patterns of Helicobacter pylori isolate resistance to fluoroquinolones, amoxicillin, clarithromycin and metronidazoles.
Southeast Asian J Trop Med Public Health
;
2006 Sep; 37(5): 970-4
Artículo
en Inglés
| IMSEAR
| ID: sea-34518
ABSTRACT
Helicobacter pylori eradication using the three antibiotic regimen of amoxicillin, clarithromycin and metronidazole often fails, making it imperative to find substitutes. The following study made use of 72 H. pylori isolates derived from pyloric antrum mucosa biopsies of gastritis and chronic dyspepsia patients treated at the Cipto Mangunkusumo National General Hospital and three private hospitals in Jakarta. Testing for H. pylori sensitivity to various antimicrobials was conducted using the disk diffusion method (Kirby Bauer) and procedures determined by the Clinical and Laboratory Standards Intitute (CLSI)/NCCLS. The resistance rates of the isolates were 100% for metronodazole, 27.8% for clarithromycin, 19.4% for amoxicillin, 6.9% for ciprofloxacin, norfloxacin and ofloxacin, 2.8% for sparfloxacin and gatifloxacin, and 1.4% for levofloxacin and moxifloxacin. Fluoroquinolons have the lowest resistance compared to amoxicillin, clarithromycin and metronidazole.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Antro Pilórico
/
Biopsia
/
Humanos
/
Enfermedad Crónica
/
Helicobacter pylori
/
Claritromicina
/
Fluoroquinolonas
/
Farmacorresistencia Bacteriana
/
Farmacorresistencia Bacteriana Múltiple
/
Dispepsia
Tipo de estudio:
Guía de Práctica Clínica
Idioma:
Inglés
Revista:
Southeast Asian J Trop Med Public Health
Año:
2006
Tipo del documento:
Artículo
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