Hemostatic alterations in beta-thalassemia/hemoglobin E patients.
Southeast Asian J Trop Med Public Health
;
1999 ; 30 Suppl 3(): 86-9
Artículo
en Inglés
| IMSEAR
| ID: sea-34622
ABSTRACT
To search for evidence of coagulation activation ex vivo, the levels of human prothrombin fragment 1+2 (F1+2) were examined in 69 beta-thalassemia/Hb E patients. Levels of protein C inhibitor (PCI) and activated protein C - PCI (APCPCI) complex were also determined in 9 of the above patients in conjunction with protein C (PC) antigen and activity, in an attempt to detect increased consumption of PC. In mean level of F1+2, there was a statistically significant difference between normal control and post-splenectomized patients (p < 0.05) but not between normal control and non-splenectomized patients (p > 0.05). The mean levels of PC activity and PC antigen in the patients were much lower than in normal controls. However, the mean levels of PCI and the mean level of APCPCI complex in the patients were not significantly different from those in normal controls (p > 0.05). The high level of F1+2 in post-splenectomized patients found in this study agreed well with clinical and other laboratory findings. The normal level of PC inhibitor and APCPCI complex found in this study provided no evidence of increased consumption of protein C in thalassemia patients.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Fragmentos de Péptidos
/
Esplenectomía
/
Trastornos de la Coagulación Sanguínea
/
Femenino
/
Humanos
/
Masculino
/
Hemoglobina E
/
Protrombina
/
Proteína C
/
Estudios de Casos y Controles
Tipo de estudio:
Estudio observacional
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Southeast Asian J Trop Med Public Health
Año:
1999
Tipo del documento:
Artículo
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