Humoral immune response following hepatitis B vaccine booster dose in children with and without prior immunization.
Southeast Asian J Trop Med Public Health
;
2000 Dec; 31(4): 623-6
Artículo
en Inglés
| IMSEAR
| ID: sea-35473
ABSTRACT
One hundred and twenty-three children who had received no, incomplete and complete primary hepatitis B vaccination but had negative or very low anti-HBs titer were immunized with a single dose of recombinant hepatitis B vaccine. Blood tests for anti-HBs were obtained at 30 +/- 5 days after the booster immunization. Twelve of 18 (66.7%) children without prior immunization (group 1) seroconverted following the single dose Seroconversion rates in children who had undetectable anti-HBs with incomplete and complete primary immunization (group 2 and 3) were 83.34% and 94.5%, respectively. All children with complete 3- dose vaccination but who had low anti-HBs titer (group 4) also seroconverted. This study confirmed that immunological memory, allowing a protective anamnestic response, lasted at least 8 years in children who had received primary HB immunization with undetectable anti-HBs. Therefore, we conclude that the booster dose after complete vaccination is not necessary in healthy children.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Tailandia
/
Humanos
/
Vacunas Sintéticas
/
Preescolar
/
Inmunización Secundaria
/
Resultado del Tratamiento
/
Vacunas contra Hepatitis B
/
Anticuerpos contra la Hepatitis B
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Southeast Asian J Trop Med Public Health
Año:
2000
Tipo del documento:
Artículo
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