The neurovirulence of flaviviruses in crab-eating monkeys (Macaca fascicularis).
Southeast Asian J Trop Med Public Health
;
1986 Dec; 17(4): 604-12
Artículo
en Inglés
| IMSEAR
| ID: sea-35566
ABSTRACT
The neurovirulent properties of attenuated dengue-2 and yellow fever (YF) vaccines, dengue-2 (DEN-2) and Japanese encephalitis (JE) viruses were studied in crab-eating monkeys (Macaca fascicularis). Number of central nervous system sites (as proportion affected) with neurovirulence (NV) lesions were compared. The results indicate that these monkeys reliably developed NV-lesion when inoculated with either JE or YF vaccine viruses (87%). NV-lesions occurred in a minority when inoculated with DEN-2 vaccine virus, were of minimal severity (9%), were probably biologically insignificant, and were of equal or less severity than lesions produced by its parental virus (10%).
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Virulencia
/
Virus de la Fiebre Amarilla
/
Femenino
/
Masculino
/
Vacunas Atenuadas
/
Vacunas Virales
/
Sistema Nervioso Central
/
Virus del Dengue
/
Virus de la Encefalitis Japonesa (Especie)
/
Flavivirus
Idioma:
Inglés
Revista:
Southeast Asian J Trop Med Public Health
Año:
1986
Tipo del documento:
Artículo
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