Immune responses following killed whole vibrio-B subunit oral cholera vaccine in human volunteers.
Southeast Asian J Trop Med Public Health
;
1989 Jun; 20(2): 201-5
Artículo
en Inglés
| IMSEAR
| ID: sea-35826
ABSTRACT
Immunogenicity of killed whole vibrio and B subunit oral cholera vaccines in American and Thai volunteers were analysed in terms of significant rise of antibody titre. Three doses of 2 x 10(11) killed vibrios and 5 mg of cholera toxin B subunit were given at two-week intervals. There were no differences in the percent of volunteers with significant rise of serum immunoglobulin G and secretory immunoglobulin A (sIgA) to cholera toxin. However, the percent with significant rises of serum antibody to whole cell V. cholerae Inaba measured by vibriocidal titre and serum immunoglobulin G, and secretory immunoglobulin A to lipopolysaccharide (LPS) measured by ELISA in American volunteers were significantly different from those in Thai volunteers (89% VS 45%, 68% VS 9% and 53% VS 0%, respectively) (p less than 0.05).
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Bangladesh
/
Humanos
/
Inmunoglobulina G
/
Vacunas contra el Cólera
/
Vacunas de Productos Inactivados
/
Cólera
/
Administración Oral
/
Adulto
/
Anticuerpos Antibacterianos
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Southeast Asian J Trop Med Public Health
Año:
1989
Tipo del documento:
Artículo
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