Attempts to infect experimentally immunosuppressed iris monkeys (Macaca iris) with Brugia malayi.
Southeast Asian J Trop Med Public Health
;
1983 Dec; 14(4): 505-9
Artículo
en Inglés
| IMSEAR
| ID: sea-35932
ABSTRACT
Iris monkeys resistant to repeated infections with B. malayi were subjected to immunosuppression by treatment with cortisone. Degree of immunosuppression was measured by (a) blood counts, (b) lymphocyte transformation to mitogens and (c) immunofluorescent antibody to microfilarial antigens. Attempts were made to infect such immunosuppressed animals with B. malayi. No microfilariae were detected in the blood of any of the Iris monkeys during the 6 months of study. There was a sharp drop in the percentages of lymphocytes, but a rise in neutrophil counts during the first week of cortisone administration. Treatment with cortisone did not alter the antibody titres. The significance of this line of approach in the understanding of filarial resistance is discussed.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Sangre
/
Brugia
/
Cortisona
/
Activación de Linfocitos
/
Terapia de Inmunosupresión
/
Filariasis
/
Recuento de Leucocitos
/
Animales
/
Macaca
/
Formación de Anticuerpos
Idioma:
Inglés
Revista:
Southeast Asian J Trop Med Public Health
Año:
1983
Tipo del documento:
Artículo
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