A field study on Nakayama and Beijing strains of Japanese encephalitis vaccines.
Southeast Asian J Trop Med Public Health
;
1995 Dec; 26(4): 689-93
Artículo
en Inglés
| IMSEAR
| ID: sea-36042
ABSTRACT
A field study to compare the immune response of children aged 1-6 years to Nakayama and Beijing strains JE vaccines was carried out in Mae Hong Son Province, northwest Thailand, where there was low incidence of JEV infection. The first and second dose of each vaccine was given 1-2 weeks apart and the third dose was 1 year after the second dose. Seroconversion rate was similarly high, about 94% in both groups of vaccinees. At 6 and 12 months after 2 doses of vaccines, the seroconversion rates dropped in both groups of vaccinees, so there were 10-20% of children (50-65% if cross protection was considered) susceptible to JEV infections during this period. After the third dose of vaccine, the seroconversion rate rose to 100% in both groups. The GMT in Bejing strain vaccinees were slightly higher than Nakayama strain JE vaccines. To reduce the number of susceptible children during 6-12 months after the second dose and for longer protection, the primary JE immunization should be 3 doses and the timing for the third dose should be at 6 months after the second dose. Either Nakayama or Beijing strain vaccine could be used in Thailand.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Tailandia
/
Femenino
/
Humanos
/
Masculino
/
Vacunas Virales
/
Serotipificación
/
Niño
/
Preescolar
/
Incidencia
/
Esquemas de Inmunización
Tipo de estudio:
Ensayo Clínico Controlado
/
Estudio de incidencia
/
Estudio pronóstico
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Southeast Asian J Trop Med Public Health
Año:
1995
Tipo del documento:
Artículo
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