Enhanced maturation and proliferation of beta-thalassemia/Hb E erythroid precursor cells in culture.
Southeast Asian J Trop Med Public Health
;
2005 Sep; 36(5): 1298-303
Artículo
en Inglés
| IMSEAR
| ID: sea-36422
ABSTRACT
Upon erythroid cell maturation in vivo, beta-thalassemic erythroid cells accumulate unmatched unstable alpha-globin chains that are believed to be a causal factor in such cell destruction. This study showed that beta-thalassemia/Hb E erythroid precursor cells from peripheral blood had accelerated maturation, and could mature to the terminal erythroid stage. During the early period of cell culture, erythroid precursor cells derived from subjects with the more severe form of beta-thalassemia/Hb E had higher rate of erythroid maturation. In addition, peripheral blood mononuclear cells from beta-thalassemia/Hb E subjects had higher erythroid proliferative potential than cells derived from normal controls. Erythroid proportion in the more severe beta-thalassemia/Hb E cases was less than that of the milder cases. Premature apoptosis was not observed during the 15 days of erythroid cell culture from both beta-thalassemia/Hb E and normal subjects.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Tailandia
/
Femenino
/
Humanos
/
Masculino
/
Células Precursoras Eritroides
/
Niño
/
Preescolar
/
Adolescente
/
Talasemia beta
/
Técnicas de Cultivo de Célula
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Southeast Asian J Trop Med Public Health
Año:
2005
Tipo del documento:
Artículo
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