A single-dose comparison of three slow-release theophylline oral preparations in healthy Thai volunteers.
Asian Pac J Allergy Immunol
;
1996 Jun; 14(1): 13-8
Artículo
en Inglés
| IMSEAR
| ID: sea-36559
ABSTRACT
The study was done to compare the pharmacokinetic characteristics of three slow-release theophylline (SRT) preparations. Twelve healthy nonsmokers were randomly assigned a single dose of the following treatments at weekly intervals Theo-Dur, Theo-24 or Xanthium orally, or aminophylline intravenously. Serially collected serum samples were analyzed for theophylline with use of fluorescence polarization immunoassay (FPIA). All three SRT preparations showed reliable absorption characteristics, but Theo-Dur had a shorter Tmax and MRT and a higher Ka. The pharmacokinetic characteristics of Theo-24 and Xanthium were similar except that Xanthium had lower bioavailability. Using single dose data for simulation of steady state pharmacokinetics, we found that a once-a-day dosage regimen with either Theo-24 or Xanthium would maintain serum levels within the therapeutic range for average non-smoking young adults whereas more frequent dosing intervals with Theo-Dur would be more appropriate. Our results argue against open substitution of SRT preparations without, close monitoring of the serum theophylline concentrations when a change is made.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Tailandia
/
Teofilina
/
Femenino
/
Humanos
/
Masculino
/
Administración Oral
/
Adulto
/
Área Bajo la Curva
/
Preparaciones de Acción Retardada
Tipo de estudio:
Ensayo Clínico Controlado
/
Estudio pronóstico
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Asian Pac J Allergy Immunol
Año:
1996
Tipo del documento:
Artículo
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