The presence of specific IgE to salicyloyl and O-methylsalicyloyl in aspirin-sensitive patients.
Asian Pac J Allergy Immunol
;
1992 Jun; 10(1): 25-32
Artículo
en Inglés
| IMSEAR
| ID: sea-36748
ABSTRACT
Certain adverse reactions to aspirin (ASA), nonsteroidal anti-inflammatory drugs (NSAIDs) and pyrazoline derivatives resemble IgE-mediated hypersensitivity. However, convincing evidence of antigen-antibody interactions or of the inhibition of the cyclooxygenase pathway of arachidonic acid metabolism leading to an increase in the generation of leukotrienes (LTs) and a decrease in the generation of prostaglandins (PGs) was not fully demonstrated. In this study, two types of specific IgE antibodies have been found in 27 serum samples from 28 ASA-sensitive patients with salicyloyl-discs and O-methylsalicyloyl-discs by Radio Allergo Sorbent Tests (RAST). The positive rates were 96.4% and 71.4%, respectively. In contrast, no positive results could be found in 10 normal donors without ASA sensitivity after ingestion of ASA 500 mg/day for 14 days. Further investigation of the chemical structure of epitopes was done by cross inhibition studies. Our results are an increasing evidence in favour of an IgE-dependent mechanism in patients suffering from ASA sensitivity. Hopefully, the determination of specific IgE antibodies will be a safe diagnostic method of ASA sensitivity in vitro.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Anciano de 80 o más Años
/
Anciano
/
Femenino
/
Humanos
/
Masculino
/
Inmunoglobulina E
/
Prueba de Radioalergoadsorción
/
Salicilatos
/
Aspirina
/
Adulto
Límite:
Aged80
Idioma:
Inglés
Revista:
Asian Pac J Allergy Immunol
Año:
1992
Tipo del documento:
Artículo
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