Epstein-Barr virus serology in the diagnosis of nasopharyngeal carcinoma.
Asian Pac J Allergy Immunol
;
2005 Mar; 23(1): 65-7
Artículo
en Inglés
| IMSEAR
| ID: sea-36795
ABSTRACT
The antibody levels to viral capsid antigen (VCA) and early antigen (EA) of Epstein-Barr virus (EBV) in 164 nasopharyngeal carcinoma (NPC) patients from Sarawak, East Malaysia were significantly higher than those in 147 sex, age and ethnically matched healthy controls. As diagnostic markers of NPC, IgG/VCA at reciprocal titers > or =160 was the most sensitive (89%, with 98% specificity), while IgA/EA at > or =5 was the most specific (100%) but the least sensitive (75%). The sensitivity and specificity of IgA/VCA at reciprocal titers > or =10 were 84% and 97%. IgA/VCA has an advantage over IgG/VCA despite the slightly lower sensitivity due to its consistently more distinct fluorescence reaction. The sensitivity and specificity can be marginally improved by a combination of two tests.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Humanos
/
Inmunoglobulina A
/
Inmunoglobulina G
/
Carcinoma
/
Biomarcadores de Tumor
/
Neoplasias Nasofaríngeas
/
Sensibilidad y Especificidad
/
Herpesvirus Humano 4
/
Técnica del Anticuerpo Fluorescente Indirecta
/
Proteínas de la Cápside
Tipo de estudio:
Estudio diagnóstico
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Asian Pac J Allergy Immunol
Año:
2005
Tipo del documento:
Artículo
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