Alpha 1-antitrypsin phenotype of children with liver diseases in Thailand.
Asian Pac J Allergy Immunol
;
1998 Mar; 16(1): 27-30
Artículo
en Inglés
| IMSEAR
| ID: sea-36894
ABSTRACT
Alpha1-antitrypsin deficiency (PiZZ) constitutes not only the most common hereditary cause of liver diseases, but also of the most prevalent metabolic diseases in need of liver transplantation. It is a codominantly inherited disorder which predisposes to chronic liver disease, usually beginning in early infancy. The purpose of the present study has been to investigate alpha 1-antitrypsin phenotype in pediatric patients with various liver diseases. Phenotypic identification of alpha 1-antitrypsin variants has been carried out in 69 children with various liver diseases and 100 healthy controls using isoelectric focusing on polyacrylamide gel slabs. PIMM represents the most common phenotype detected in both groups (92% in the group with liver diseases and 88% in normal controls). We could detect PiZZ in only one healthy child but in none of those with liver diseases. Consequently alpha 1-antitrypsin deficiency does not appear to be a common cause for liver disease among children in Thailand. Further studies are necessary to elucidate the frequency of various alpha 1-antitrypsin variants and the clinical relevance with respect to liver diseases in Thailand.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Fenotipo
/
Tailandia
/
Humanos
/
Niño
/
Deficiencia de alfa 1-Antitripsina
/
Electroforesis en Gel de Poliacrilamida
/
Hepatopatías
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Asian Pac J Allergy Immunol
Año:
1998
Tipo del documento:
Artículo
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