Prevalence and clinical relevance of serum anti-p53 antibodies in patients with cholangiocarcinoma.
Asian Pac J Allergy Immunol
;
2000 Sep; 18(3): 173-6
Artículo
en Inglés
| IMSEAR
| ID: sea-36955
ABSTRACT
Cholangiocarcinoma (CCA) constitutes carcinoma of the bile duct found at a high prevalence in northeastern Thailand. In the present study, we examined the sera of altogether 82 Thai CCA patients for the presence of anti-p53 antibodies in order to investigate a role of the tumor suppressor gene, p53 in the carcinogenesis. Our results revealed anti-p53 antibodies in 7.3% of the cases tested, which conforms to the prevalence rate of p53 gene mutation recently reported at 5% among Thai patients. With limited number of the patients, anti-p53 antibodies were rapidly detected more frequently among patients with peripheral tumors than those with central tumors. However, further studies is required to establish significance and prognostic value of the antibodies in the context of CCA.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Pronóstico
/
Neoplasias de los Conductos Biliares
/
Conductos Biliares Intrahepáticos
/
Anciano
/
Femenino
/
Humanos
/
Masculino
/
Albúmina Sérica
/
Ensayo de Inmunoadsorción Enzimática
/
Alfa-Fetoproteínas
Tipo de estudio:
Estudio observacional
/
Estudio de prevalencia
/
Estudio pronóstico
/
Factores de riesgo
Idioma:
Inglés
Revista:
Asian Pac J Allergy Immunol
Año:
2000
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS