Preliminary clinical evaluation of a protein chip for tumor marker serodiagnosis of various cancers.
Asian Pac J Allergy Immunol
;
2003 Sep; 21(3): 171-8
Artículo
en Inglés
| IMSEAR
| ID: sea-37021
ABSTRACT
This preliminary study aimed to investigate sensitivity and specificity of a protein chip system for multi-tumor marker serodiagnosis of ten types of cancers, and to understand the possible clinical applications of this protein chip for the Thai population. The specific cancers diagnosed by this protein chip are lung, breast, liver, cervix, colo-rectal, stomach, ovary, esophagus, prostate and pancreas cancers. We analyzed 215 serum samples of which 165 were obtained from clinically confirmed cancer patients and 50 from healthy people with no evidence of cancer. The sensitivity and specificity of the protein chip were 82.4% and 94.0%, respectively. The success rate of the protein chip for detecting all 10 types of cancers varied from 57% to 100%. The value of the simultaneous measurement of multiple tumor markers using the protein chip for cancer screening lied in the higher sensitivity compared to using single tumor markers for each type of cancer. In short, protein chips may be useful in mass screening for cancer during health checkups as well as for metastasis follow-up of cancer patients.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Tailandia
/
Anciano de 80 o más Años
/
Anciano
/
Femenino
/
Humanos
/
Masculino
/
Pruebas Serológicas
/
Antígenos de Carbohidratos Asociados a Tumores
/
Alfa-Fetoproteínas
/
Antígeno Carcinoembrionario
Tipo de estudio:
Estudio diagnóstico
/
Estudios de evaluación
/
Estudio de tamizaje
Límite:
Aged80
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Asian Pac J Allergy Immunol
Año:
2003
Tipo del documento:
Artículo
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