Predisposing factors for nevirapine toxicity among AIDS patients with low baseline CD4 count.
Asian Pac J Allergy Immunol
;
2007 Jun-Sep; 25(2-3): 147-54
Artículo
en Inglés
| IMSEAR
| ID: sea-37084
ABSTRACT
The objective of the study was to determine the predisposing factors and incidence of toxicity among AIDS patients treated with a nevirapine (NVP)-based regimen in clinical practice. A retrospective cohort study of representative samples of AIDS patients treated with a NVP-based regimen was performed. A total of 206 adult HIV/AIDS cases with median age (IQR) 33 years (range, 29-38 years), 51% male, treated between January 2004-December 2005, were included. Most (92.2%) of the patients were naïve to antiretroviral drug. The incidence of NVP toxicity was 1.09/100 person-months. The median onset time was 4 weeks post NVP initiation (2.57 weeks for skin toxicity and 12.43 weeks for hepatic toxicity). History of drug allergy and NVP toxicity were significantly associated (p = 0.006), as were sulfamethoxazole allergy and toxicity (p = 0.015). Regarding concomitant medication, concurrent anti-tuberculosis drugs significantly increased the risk of NVP associated liver toxicity (p = 0.001). Therefore, it is important to monitor adverse events from NVP, including liver function tests among HIV/AIDS patients with history of drug allergy, especially against sulfamethoxazole, and those concurrently treated with antituberculosis drugs.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Tuberculosis
/
Femenino
/
Humanos
/
Masculino
/
Infecciones por VIH
/
Causalidad
/
Estudios Retrospectivos
/
Estudios de Cohortes
/
VIH
/
Infecciones Oportunistas Relacionadas con el SIDA
Tipo de estudio:
Estudio de etiología
/
Estudio de incidencia
/
Estudio observacional
/
Factores de riesgo
Idioma:
Inglés
Revista:
Asian Pac J Allergy Immunol
Año:
2007
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS