HLA-A, -B and -DR allele and haplotype frequencies in Malays.
Asian Pac J Allergy Immunol
;
2007 Mar; 25(1): 47-51
Artículo
en Inglés
| IMSEAR
| ID: sea-37097
ABSTRACT
One thousand four hundreds and forty-five Malays registered with the Malaysian Marrow Donor Registry were typed for HLA-A, HLA-B and HLA-DR. Fifteen HLA-A, twenty nine HLA-B and fourteen HLA-DR alleles were detected. The most common HLA-A alleles and their frequencies were HLA-A24 (0.35), HLA-A11 (0.21) and HLA-A2 (0.15). The most common HLA-B alleles were HLA-B15 (0.26), HLA-B35 (0.11) and HLA-B18 (0.10) while the most common HLA-DR alleles were HLA-DR15 (0.28), HLA-DR12 (0.27) and HLA-DR7 (0.10). A24-B15-DR12 (0.047), A24-B15-DR15 (0.03) and the A24-B35-DR12 (0.03) were the most frequent haplotypes. This data may be useful in determining the probability of finding a matched donor and for estimating the incidence of HLA associated diseases.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Haplotipos
/
Femenino
/
Humanos
/
Masculino
/
Prueba de Histocompatibilidad
/
Antígenos HLA-A
/
Antígenos HLA-B
/
Antígenos HLA-DR
/
Estudios de Cohortes
/
Alelos
Tipo de estudio:
Estudio de etiología
/
Estudio de incidencia
/
Estudio observacional
/
Factores de riesgo
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Asian Pac J Allergy Immunol
Año:
2007
Tipo del documento:
Artículo
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