Dengue virus specific T cell responses to live attenuated monovalent dengue-2 and tetravalent dengue vaccines.
Asian Pac J Allergy Immunol
;
2000 Dec; 18(4): 227-35
Artículo
en Inglés
| IMSEAR
| ID: sea-37121
ABSTRACT
The proliferative T cell responses to dengue vaccines were studied using the parental strains of dengue vaccines as antigens in 26 dengue immune individuals who resided in Bangkok which is the endemic area of dengue infection. The magnitude of the T cell responses in subjects with flavivirus cross-reactive neutralizing antibody was much higher and the cross-reactivity was broader than in those with dengue serotype-specific neutralizing antibodies, Japanese encephalitis (JE) specific antibodies or dengue cross-reactive antibodies. The T cell response in those with neutralizing antibody against a single serotype or in those who had dengue cross-reactive neutralizing antibody was relatively low, independent of the level or degree of cross-reactivity of the antibody. Evaluation of the proliferative T cell responses in 8 recipients of the monovalent dengue-2 (16681-PDK53) or the tetravalent dengue vaccines demonstrated that both vaccines induced high levels of neutralizing antibody as well as high levels of T cell responses to all serotypes of dengue virus. These results indicate that the evaluated dengue vaccines efficiently induced humoral and cell mediated immunity comparable to natural infection with dengue virus.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Humanos
/
Masculino
/
Pruebas de Neutralización
/
Vacunas Atenuadas
/
Vacunas Virales
/
Linfocitos T
/
División Celular
/
Adolescente
/
Adulto
/
Dengue Grave
Idioma:
Inglés
Revista:
Asian Pac J Allergy Immunol
Año:
2000
Tipo del documento:
Artículo
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