Lack of association between Helicobacter pylori and laryngeal carcinoma.

ABSTRACT

OBJECTIVE: To survey the role of Helicobacter pylori at the tissue level as a cause of squamous cell carcinoma of the larynx. DESIGN: A case-control study. SETTING: In an Otolaryngology Ward at an academic university. SUBJECTS: Patients with laryngeal cancer as cases and patients with benign laryngeal lesion as controls. MAIN OUTCOME MEASURE: In all subjects, specimens of laryngeal tissue were examined by rapid urease test while histopathologic examination was achieved to detect H. Pylori. RESULTS: Totally, 44 patients (42 men and 2 women) with squamous cell carcinoma of larynx and 30 patients (24 men and 6 women) with benign laryngeal lesions (polyp, nodule, granuloma) were studied, none of which were infected with the bacterium. CONCLUSION: Our results did not show H. Pylori infection among patients with laryngeal cancer (SCC) or benign laryngeal lesions. .