Immunoglobulin heavy and light chain isotypes in multiple myeloma patients.
Artículo
en Inglés
| IMSEAR
| ID: sea-37841
ABSTRACT
The frequency of expression of immunoglobulin (Ig) light and heavy chain isotypes was analyzed in myeloma proteins (M-proteins) from sera of 40 Indian patients with clinically established multiple myeloma. Patients samples were screened by a combination of electrophoresis, immunoelectrophoresis (IEP) and ELISA techniques in this study. We found that majority of the myeloma proteins (58%) were of the IgG isotype followed by IgA (24%) and biclonal gammopathy associated with IgG and IgA (5%). Both kappa and lambda light chains were associated with the heavy chain isotypes. We recommend the triangular combination for detection of M-proteins and biclonal gammopathy of cancerous plasma cells as biomarkers for diagnosis of myeloma.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Pronóstico
/
Humanos
/
Inmunoglobulinas
/
Ensayo de Inmunoadsorción Enzimática
/
Inmunoelectroforesis
/
Cadenas Pesadas de Inmunoglobulina
/
Cadenas Ligeras de Inmunoglobulina
/
Mieloma Múltiple
Tipo de estudio:
Estudio pronóstico
Idioma:
Inglés
Año:
2007
Tipo del documento:
Artículo
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