Anti-tumour activity of Ruta graveolens extract.
Artículo
en Inglés
| IMSEAR
| ID: sea-37856
ABSTRACT
An extract of Ruta graveolens was found to be cytotoxic to Dalton's lymphoma ascites (DLA), Ehrlich ascites carcinoma (EAC) and L929 cells in culture (IC100=16 mg/ml) and also to increase the lifespan of tumour bearing animals. The extract further decreased solid tumours developing from DLA and EAC cells when given simultaneously with elongation of the lifespan of tumour-bearing animals. A homeopathic preparation of Ruta graveolens (200 c) was equally effective. Neither was effective for reducing already developed tumours. The Ruta graveolens extract was found to scavenge hydroxyl radicals and inhibit lipid peroxidation at low concentrations. However, at higher concentrations the extract acted as a prooxidant as inhibition of lipid peroxidation and scavenging of hydroxyl radical was minimal. These data indicates that the prooxidant activity of Ruta graveolens may be responsible for the cytocidal action of the extract and its ability to produce tumour reduction.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Femenino
/
Células Tumorales Cultivadas
/
Extractos Vegetales
/
Carcinoma de Ehrlich
/
Peroxidación de Lípido
/
Depuradores de Radicales Libres
/
Radical Hidroxilo
/
Ensayos Antitumor por Modelo de Xenoinjerto
/
Ruta
/
Linfoma
Idioma:
Inglés
Año:
2006
Tipo del documento:
Artículo
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