Isobolographically additive anticonvulsant activity between Centella asiatica's ethyl acetate fraction and some antiepileptic drugs.
Artículo
en Inglés
| IMSEAR
| ID: sea-39320
ABSTRACT
OBJECTIVE:
To investigate interaction between orally given Centella asiatica's ethyl acetate fraction (EACA) and intraperitoneally administered antiepileptic drugs (AEDs), namely, phenytoin, valproate and gabapentin. MATERIAL ANDMETHOD:
Isobolographic analysis was used to evaluate the interaction between EACA and AEDs in terms of protection of mice in the pentylenetetrazole test. Rotarod test was used to evaluate neurotoxicity.RESULTS:
When given alone, the median effective dose of phenytoin, valproate and gabapentin were found to be 13, 104, and 310 mg/kg BW, respectively, whereas the corresponding values in the presence of EACA were 5, 29 and 79 mg/kg BW. Together with isobolographic analysis, the results obtained indicated an additive effect among all combinations tested. In relation to neurotoxicity, combination of gabapentin and EACA demonstrated a broader margin between the effective dose and the neurotoxic dose while the other two combinations did not.CONCLUSION:
The present finding suggested a potential of Centella asiatica to be developed as an adjunctive medication for epileptic patients.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Convulsiones
/
Masculino
/
Extractos Vegetales
/
Centella
/
Interacciones de Hierba-Droga
/
Modelos Animales de Enfermedad
/
Quimioterapia Combinada
/
Animales
/
Fitoterapia
/
Ratones
Tipo de estudio:
Estudio pronóstico
Idioma:
Inglés
Año:
2005
Tipo del documento:
Artículo
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