Your browser doesn't support javascript.
loading
Isobolographically additive anticonvulsant activity between Centella asiatica's ethyl acetate fraction and some antiepileptic drugs.
Artículo en Inglés | IMSEAR | ID: sea-39320
ABSTRACT

OBJECTIVE:

To investigate interaction between orally given Centella asiatica's ethyl acetate fraction (EACA) and intraperitoneally administered antiepileptic drugs (AEDs), namely, phenytoin, valproate and gabapentin. MATERIAL AND

METHOD:

Isobolographic analysis was used to evaluate the interaction between EACA and AEDs in terms of protection of mice in the pentylenetetrazole test. Rotarod test was used to evaluate neurotoxicity.

RESULTS:

When given alone, the median effective dose of phenytoin, valproate and gabapentin were found to be 13, 104, and 310 mg/kg BW, respectively, whereas the corresponding values in the presence of EACA were 5, 29 and 79 mg/kg BW. Together with isobolographic analysis, the results obtained indicated an additive effect among all combinations tested. In relation to neurotoxicity, combination of gabapentin and EACA demonstrated a broader margin between the effective dose and the neurotoxic dose while the other two combinations did not.

CONCLUSION:

The present finding suggested a potential of Centella asiatica to be developed as an adjunctive medication for epileptic patients.
Asunto(s)
Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Convulsiones / Masculino / Extractos Vegetales / Centella / Interacciones de Hierba-Droga / Modelos Animales de Enfermedad / Quimioterapia Combinada / Animales / Fitoterapia / Ratones Tipo de estudio: Estudio pronóstico Idioma: Inglés Año: 2005 Tipo del documento: Artículo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Convulsiones / Masculino / Extractos Vegetales / Centella / Interacciones de Hierba-Droga / Modelos Animales de Enfermedad / Quimioterapia Combinada / Animales / Fitoterapia / Ratones Tipo de estudio: Estudio pronóstico Idioma: Inglés Año: 2005 Tipo del documento: Artículo