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The Atorvastatin Goal Achievement Across Risk Levels: (ATGOAL) study in Thailand.
Artículo en Inglés | IMSEAR | ID: sea-39430
ABSTRACT

OBJECTIVE:

To evaluate the efficacy and safety of atorvastatin at the starting doses of 10, 20, 40 mg and evaluate the effectiveness of 1 step titrate up regimen. MATERIAL AND

METHOD:

Two hundred and forty two subjects with dyslipidemia were enrolled and assigned the appropriate dose in relation to their individual cardiovascular risk status and baseline LDL-C levels. If the NCEP targets were not achieved, the doses were titrated up at week 4 and the primary efficacy was evaluated at week 8.

RESULTS:

A majority of subjects (88.8%) achieved their LDL-C goals at week 8. Almost all of the subject's LDL-C levels reached their goals by week 2 and 4 (81.6% and 87.1%, respectively). Only 10.7% (n = 25) required the sole titration. Each dose provided significant decreases in LDL-C (average -46.4%). Only 36 subjects experienced treatment related adverse events, the majority of these were in the high-risk group (n = 22) with only one subject registering a serious adverse event.

CONCLUSION:

Atorvastatin is effective and safe for Thai patients with dyslipidemia. The appropriate starting dose has contributed in the achievement of cholesterol reduction.
Asunto(s)
Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Pirroles / Anciano de 80 o más Años / Anciano / Femenino / Humanos / Masculino / Adolescente / Resultado del Tratamiento / Medición de Riesgo / Inhibidores de Hidroximetilglutaril-CoA Reductasas Tipo de estudio: Estudio de etiología / Factores de riesgo Límite: Aged80 Idioma: Inglés Año: 2007 Tipo del documento: Artículo

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Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Pirroles / Anciano de 80 o más Años / Anciano / Femenino / Humanos / Masculino / Adolescente / Resultado del Tratamiento / Medición de Riesgo / Inhibidores de Hidroximetilglutaril-CoA Reductasas Tipo de estudio: Estudio de etiología / Factores de riesgo Límite: Aged80 Idioma: Inglés Año: 2007 Tipo del documento: Artículo