Linear IgA bullous dermatosis of childhood: a long-term study.
Artículo
en Inglés
| IMSEAR
| ID: sea-39612
ABSTRACT
BACKGROUND:
Linear IgA bullous dermatosis (LAD) of childhood is a rare acquired subepidermal blistering disease of young children. Most of the studies were reported from the USA and European countries.METHOD:
Twelve cases of Thai patients diagnosed as LAD of childhood were analyzed concerning clinical, histopathological, immunopathological findings including treatment responses and courses compared with those of Caucasians.RESULT:
The mean age of onset was 5.1 years. The areas of common involvement were the perioral region, lower abdomen, perineum, buttock, inner thighs and extremities. Histopathology in half of the cases showed features of dermatitis herpetiformis or bullous pemphigoid. All patients had positive linear IgA band at the basement membrane zone (BMZ) by direct immunofluorescence. Only one patient had positive circulating anti BMZ antibody at the titer of 110. Most patients responded well to dapsone. The mean duration before remission was 1.9 years.CONCLUSION:
Our study in Thai patients with LAD of childhood produced data similar to previous studies carried out in the Caucasian nations.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Pronóstico
/
Tailandia
/
Índice de Severidad de la Enfermedad
/
Femenino
/
Humanos
/
Masculino
/
Inmunoglobulina A
/
Niño
/
Preescolar
/
Antiinflamatorios no Esteroideos
Tipo de estudio:
Estudio diagnóstico
/
Estudios de evaluación
/
Estudio pronóstico
País/Región como asunto:
Asia
Idioma:
Inglés
Año:
1999
Tipo del documento:
Artículo
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