Histomorphological study of indomethacin induced gastrointestinal lesions in rat.
Bangladesh Med Res Counc Bull
;
1993 Dec; 19(3): 94-8
Artículo
en Inglés
| IMSEAR
| ID: sea-397
ABSTRACT
This study was undertaken in Long Evans rat to investigate the effect of a single therapeutic as well as toxic dose of indomethacin on the gastrointestinal mucosa. The effect was studied morphologically six hours after oral administration of the drug. The affected tissue was then examined histologically. The histomorphological evaluation revealed that the drug has induced acute hemorrhagic erosive gastritis in the fasted animals (6 mg/Kg body weight) where as in normally fed (10 mg/kg body weight) rats the small intestinal mucosal inflammation and erosions were predominant.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Ratas
/
Ratas Endogámicas
/
Femenino
/
Masculino
/
Indometacina
/
Administración Oral
/
Relación Dosis-Respuesta a Droga
/
Mucosa Gástrica
/
Gastritis
/
Mucosa Intestinal
Idioma:
Inglés
Revista:
Bangladesh Med Res Counc Bull
Año:
1993
Tipo del documento:
Artículo
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