DTH responsiveness of HIV-infected Thai adults.
Artículo
en Inglés
| IMSEAR
| ID: sea-39984
ABSTRACT
A study was carried out in Thailand to determine the frequency of reactivity to delayed-type hypersensitivity (DTH) skin tests used for the staging of HIV patients in the United States. A four-antigen panel which included tetanus toxoid (110), Candida (110), mumps and Trichophyton antigens was assessed in 221 adult subjects from across the full immunological spectrum of HIV disease. Complete anergy was found in 38 per cent of 73 subjects with CD4 counts of 0-200 cells/ml and in 6 per cent of 78 subjects with 201-400 cells/ml. Partial anergy (response to 1 of 4 antigens) was found in 26 per cent of the 0-200 cell/ml group and decreased progressively with increasing CD4 cell count. Results suggested that a 3-member recall antigen panel would provide nearly all the clinically useful information gained by the more standard 4-member panel. In conclusion, DTH skin testing was confirmed to provide a method of assessing the integrity of cellular immune function of HIV-infected Thai adults which correlated with disease progression.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Pronóstico
/
Tailandia
/
Índice de Severidad de la Enfermedad
/
Femenino
/
Humanos
/
Masculino
/
Pruebas Cutáneas
/
Biomarcadores
/
Distribución de Chi-Cuadrado
/
Infecciones por VIH
Tipo de estudio:
Estudio diagnóstico
/
Estudio pronóstico
País/Región como asunto:
Asia
Idioma:
Inglés
Año:
2000
Tipo del documento:
Artículo
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