Methyldopa supplement for resistant essential hypertension: a prospective randomized placebo control crossover study.
Artículo
en Inglés
| IMSEAR
| ID: sea-40137
ABSTRACT
BACKGROUND:
Resistant hypertension is an important public health problem, its prevalence varies between 30 to 50 per cent. However, there is no definite recommendation for the treatment of resistant hypertension (HT). MATERIAL ANDMETHOD:
A prospective randomized placebo control crossover study in resistant HT was designed to compare safety and efficacy between methyldopa 250 mg twice daily and placebo using ambulatory blood pressure monitoring.RESULTS:
87 from 1,112 cases (7.82%) from the hypertension clinic of Vajira Hospital were found to have clinical resistant HT and 40 cases were accepted to enrolled in the study. 23 cases of true resistant HT proceeded to the treatment phase of the study and all of them completed the study. Methyldopa reduced systolic blood pressure (BP) from 153.67 to 135.23 mmHg, or -18.44 mmHg (95% confidence interval 15.13-21.75). Diastolic BP was reduced from 86.42 to 74.90 mmHg, or -11.52 mmHg (95% confidence interval 9.41-13.63).CONCLUSION:
The addition of methyldopa to the optimal medical therapy contributed to the improvement of BP control among patients with resistant HT.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Humanos
/
Método Doble Ciego
/
Estudios Prospectivos
/
Estudios Cruzados
/
Adulto
/
Quimioterapia Combinada
/
Hipertensión
/
Metildopa
/
Antihipertensivos
Tipo de estudio:
Ensayo Clínico Controlado
/
Guía de Práctica Clínica
/
Estudio observacional
Idioma:
Inglés
Año:
2003
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS