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Primary pigmented nodular adrenocortical disease with synaptophysin immunoreactivity in two thai children.
Artículo en Inglés | IMSEAR | ID: sea-40396
ABSTRACT
This paper reports the cases of two Thai children diagnosed with primary pigmented nodular adrenocortical disease (PPNAD). The first was a thirteen and a half year old male who presented with Cushing syndrome for three years and severe osteoporosis. He had hypercortisolemia, a non-suppressible dexamethasone suppression test, and low serum ACTH. A CT scan showed slight enlargement of both adrenal glands. A bilateral adrenalectomy was performed. The second case was a thirteen-year old female who presented with mild Cushing syndrome for one year with paradoxical response to high-dose dexamethasone suppression test. An MRI revealed suspected microadenoma of the left adrenal gland. Blood sampling showed a higher cortisol level from the left adrenal vein than from the right. A left adrenalectomy was performed, followed by a right adrenalectomy four months later. The pathologies were compatible with PPNAD. Immunostaining for synaptophysin was done in both patients. The cells in the adrenocortical micronodules of both cases were stained intensely with antiserum for synaptophysin, whereas the surrounding adrenal cortex did not.
Asunto(s)
Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Trastornos de la Pigmentación / Tailandia / Femenino / Humanos / Masculino / Adolescente / Sinaptofisina / Enfermedades de la Corteza Suprarrenal / Síndrome de Cushing País/Región como asunto: Asia Idioma: Inglés Año: 2007 Tipo del documento: Artículo

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Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Trastornos de la Pigmentación / Tailandia / Femenino / Humanos / Masculino / Adolescente / Sinaptofisina / Enfermedades de la Corteza Suprarrenal / Síndrome de Cushing País/Región como asunto: Asia Idioma: Inglés Año: 2007 Tipo del documento: Artículo