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Pathologically different features and fibrosis scores in chronic hepatitis C genotypes 3 and 1.
Artículo en Inglés | IMSEAR | ID: sea-40548
ABSTRACT

BACKGROUND:

Chronic hepatitis C genotypes 3 and 1 are the two most common genotypes in Thailand.

OBJECTIVE:

Identify the pathologically different features between genotypes 3 and land to compare the fibrosis score of Knodell HAI and Ishak modified HAI. MATERIAL AND

METHOD:

The pathological features of 114 liver biopsies were evaluated.

RESULTS:

Steatosis was more commonly found in genotype 3 than in genotype 1 (97.1% vs. 77.8%, p = 0.001). Portal lymphoid follicles were commonly found, but bile duct damage was uncommon. The majority of portal tracts showed partial involvement. The majority of patients had Knodell fibrosis 1 and Ishak fibrosis 3.

CONCLUSION:

Steatosis is significantly more common in genotype 3, while other features do not show any differences. The portal tracts show partial involvement because inflammatory cells tend to aggregate and form lymphoid follicles. The most comparable fibrosis scores are Knodell fibrosis 1 and Ishak fibrosis 3.
Asunto(s)
Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Tailandia / Biopsia / Índice de Severidad de la Enfermedad / Femenino / Humanos / Masculino / Hepacivirus / Adulto / Hepatitis C Crónica / Hígado Graso Tipo de estudio: Estudio pronóstico País/Región como asunto: Asia Idioma: Inglés Año: 2007 Tipo del documento: Artículo

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Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Tailandia / Biopsia / Índice de Severidad de la Enfermedad / Femenino / Humanos / Masculino / Hepacivirus / Adulto / Hepatitis C Crónica / Hígado Graso Tipo de estudio: Estudio pronóstico País/Región como asunto: Asia Idioma: Inglés Año: 2007 Tipo del documento: Artículo