Your browser doesn't support javascript.
loading
The expression of cyclooxygenase-2 in human umbilical vein endothelial cell culture from preeclampsia.
Artículo en Inglés | IMSEAR | ID: sea-41479
ABSTRACT
We have shown the HUVEC from normal pregnancy contained COX-1 protein but not COX-2 protein and released 6-keto-PGF1 alpha 277 +/- 5 ng/ml (for 24 h). In contrast, HUVEC from preeclampsia contained both COX-1 and COX-2 protein and released significantly lesser amounts of 6-keto-PGF1 alpha (159 +/- 8 ng/ml for 24 h; p < 0.05). Thus, COX-2 is expressed in HUVEC from preeclampsia but not in normal pregnancy and affects the release of prostacyclin suggesting the involvement of COX-2 in the pathogenesis of preeclampsia. The development of selective inhibitors of COX-2 may have a potential role in prevention and treatment of preeclampsia.
Asunto(s)
Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Peroxidasas / Preeclampsia / Venas Umbilicales / Femenino / Humanos / Embarazo / Endotelio Vascular / Células Cultivadas / Western Blotting / Prostaglandina-Endoperóxido Sintasas Idioma: Inglés Año: 1999 Tipo del documento: Artículo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Peroxidasas / Preeclampsia / Venas Umbilicales / Femenino / Humanos / Embarazo / Endotelio Vascular / Células Cultivadas / Western Blotting / Prostaglandina-Endoperóxido Sintasas Idioma: Inglés Año: 1999 Tipo del documento: Artículo