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DNA typing of the HLA-A, -B and -C genes: possible MHC class I haplotypes in the northeastern-Thais.
Artículo en Inglés | IMSEAR | ID: sea-41625
ABSTRACT
The phenotype and gene frequencies of HLA class I were studied in the Northeastern Thai population. Blood samples were collected from 100 unrelated healthy northeastern-Thais. HLA-A, -B and -Cw alleles were determined using the polymerase chain reaction- amplification refractory mutation system (PCR-ARMS). 12 HLA-A, 20 HLA-B and 14 HLA-Cw alleles were found. Linkage disequilibrium analysis indicated the existence of 7 HLA-A-B and 19 HLA-B-Cw haplotypes. A*0207-Cw*01-B*4601 was the most common possible haplotype in this population. These results provide regional basic information for further studies in anthropology, organ transplantation and MHC disease associations in the northeastern-Thais.
Asunto(s)
Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Fenotipo / Polimorfismo Genético / Tailandia / Haplotipos / Humanos / Antígenos HLA-A / Antígenos HLA-B / Antígenos HLA-C / Etnicidad / Distribución de Chi-Cuadrado País/Región como asunto: Asia Idioma: Inglés Año: 1997 Tipo del documento: Artículo

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Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Fenotipo / Polimorfismo Genético / Tailandia / Haplotipos / Humanos / Antígenos HLA-A / Antígenos HLA-B / Antígenos HLA-C / Etnicidad / Distribución de Chi-Cuadrado País/Región como asunto: Asia Idioma: Inglés Año: 1997 Tipo del documento: Artículo