Fecal alpha1--antitrypsin in healthy and intestinal-disorder Thai children.
Artículo
en Inglés
| IMSEAR
| ID: sea-41751
ABSTRACT
OBJECTIVE:
Determine the normal FA1-AT level in random wet stool of Thai children using RID and NPL, and to study the correlation between RID and NPL methods for measurement of FA1-AT. MATERIAL ANDMETHOD:
Random stool samples were collected from healthy children and intestinal-disorders patients. Alpha1-antitrypsin (FA1-AT) in wet stool samples was measured by nephelometry (NPL) and radial-immunodiffusion (RID) methods.RESULTS:
Newborn infants had the highest FA1-AT level during the first day of life and declined to the same level as older children on day 3-4. Median and geometric mean of FA1-AT levels by NPL from healthy children aged 1 month-15 years was 1.23 and 1.11 mg/dL respectively. FA1-AT levels by NPL from children with severe intestinal disorders, displaying median and geometric mean at 6.77 and 12.39 mg/dL respectively, were much higher than healthy children. The RID and NPL methods showed a correlation of r = 0.87 (p < 0.01) and R2 = 0.75.CONCLUSION:
Random FA1-AT assay in wet stool is a non-invasive and simple test for supporting diagnosis of protein-losing enteropathy.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Enteropatías Perdedoras de Proteínas
/
Valores de Referencia
/
Tailandia
/
Femenino
/
Humanos
/
Masculino
/
Recién Nacido
/
Niño
/
Preescolar
/
Alfa 1-Antitripsina
Tipo de estudio:
Estudio observacional
País/Región como asunto:
Asia
Idioma:
Inglés
Año:
2007
Tipo del documento:
Artículo
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