Dysplastic nodules and small primary carcinoma of the liver: a study detecting the early morphological changes during hepatocarcinogenesis.
Artículo
en Inglés
| IMSEAR
| ID: sea-43360
ABSTRACT
OBJECTIVE:
Detect the early histological changes relating to human hepatocarcinogenesis in three nodular hepatocellular lesions. MATERIAL ANDMETHOD:
Three cases of dysplastic nodules and one of small hepatocellular carcinoma were obtained from the authors' surgical-pathology file during 2000-2005 for a histopathological study in relevance to the early changes during hepatocarcinogenesis by employing hematoxylin and eosin stain, as well as some immunohistochemical staining.RESULTS:
One nodular hepatocellular lesion, diagnosed as a complex lesion of focal nodular hyperplasia contained a microscopic focus (1.5 mm in diameter) of combined hepatocellular and cholangiocarcinoma.CONCLUSION:
The small dysplastic hepatocytes subjected to neoplastic transformation combined hepatocellular and cholangiocarcinoma and are the precursorial cells of hepatocellular carcinoma. Chronic viral hepatitis B or C, aflatoxin B, and nitrosamine(s), as well as some nodular hepatocellular lesions share distinct roles in the complex process of hepatocarcinogenesis pertaining to this Southeast Asian country.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Factores de Tiempo
/
Femenino
/
Humanos
/
Masculino
/
Estudios Retrospectivos
/
Adulto
/
Hepatocitos
/
Diagnóstico Precoz
/
Neoplasias Hepáticas
/
Persona de Mediana Edad
Tipo de estudio:
Estudio diagnóstico
/
Estudio observacional
/
Estudio de tamizaje
Idioma:
Inglés
Año:
2007
Tipo del documento:
Artículo
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