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Dysplastic nodules and small primary carcinoma of the liver: a study detecting the early morphological changes during hepatocarcinogenesis.
Artículo en Inglés | IMSEAR | ID: sea-43360
ABSTRACT

OBJECTIVE:

Detect the early histological changes relating to human hepatocarcinogenesis in three nodular hepatocellular lesions. MATERIAL AND

METHOD:

Three cases of dysplastic nodules and one of small hepatocellular carcinoma were obtained from the authors' surgical-pathology file during 2000-2005 for a histopathological study in relevance to the early changes during hepatocarcinogenesis by employing hematoxylin and eosin stain, as well as some immunohistochemical staining.

RESULTS:

One nodular hepatocellular lesion, diagnosed as a complex lesion of focal nodular hyperplasia contained a microscopic focus (1.5 mm in diameter) of combined hepatocellular and cholangiocarcinoma.

CONCLUSION:

The small dysplastic hepatocytes subjected to neoplastic transformation combined hepatocellular and cholangiocarcinoma and are the precursorial cells of hepatocellular carcinoma. Chronic viral hepatitis B or C, aflatoxin B, and nitrosamine(s), as well as some nodular hepatocellular lesions share distinct roles in the complex process of hepatocarcinogenesis pertaining to this Southeast Asian country.
Asunto(s)
Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Factores de Tiempo / Femenino / Humanos / Masculino / Estudios Retrospectivos / Adulto / Hepatocitos / Diagnóstico Precoz / Neoplasias Hepáticas / Persona de Mediana Edad Tipo de estudio: Estudio diagnóstico / Estudio observacional / Estudio de tamizaje Idioma: Inglés Año: 2007 Tipo del documento: Artículo

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Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Factores de Tiempo / Femenino / Humanos / Masculino / Estudios Retrospectivos / Adulto / Hepatocitos / Diagnóstico Precoz / Neoplasias Hepáticas / Persona de Mediana Edad Tipo de estudio: Estudio diagnóstico / Estudio observacional / Estudio de tamizaje Idioma: Inglés Año: 2007 Tipo del documento: Artículo