Thrombophilia profile in Thai patients with arterial thrombotic disorders.
Artículo
en Inglés
| IMSEAR
| ID: sea-44324
ABSTRACT
BACKGROUND:
Arterial thrombosis is attributed mainly to atherosclerosis and the roles of hypercoagulability remain unclear In addition, there are ethnic variations in thrombophilia profiles.OBJECTIVE:
The authors performed a survey of the thrombophilia profile in Thai patients with arterial thrombosis MATERIAL ANDMETHOD:
The authors analyzed 103 consecutive cases of proven arterial thrombosis and requested thrombophilia profile in Chulalongkorn Hospital during 2003-2004. The mean age was 42.5 years. The proportions of stroke, peripheral arteries, and other sites were 70.9%, 22.3% and 6.8%, respectively.RESULTS:
Abnormal profile was found in 35.0% with the prevalence of hyperhomocysteinemia, low protein S, antiphospholipid antibody and low protein C was 15.5%, 12.6%, 9.7%, and 5.8%, respectively. There was no difference in clinical characteristics between cases with or without detectable abnormalities. However, the authors found significant associations of low protein S with poor outcome and HIV seropositivity with antiphospholipid.CONCLUSION:
The present study found that the defective protein C pathway may be the most common thrombophilia found in Thais with arterial thrombosis. Future study is required to prove the cause-effect relationship and its clinical significance.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Arteriopatías Oclusivas
/
Tailandia
/
Trombosis
/
Anciano
/
Femenino
/
Humanos
/
Masculino
/
Oportunidad Relativa
/
Niño
/
Preescolar
Tipo de estudio:
Estudio de etiología
/
Estudio de prevalencia
/
Factores de riesgo
País/Región como asunto:
Asia
Idioma:
Inglés
Año:
2006
Tipo del documento:
Artículo
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