A randomized, open-label, comparative trial of BID and TID dosing of saquinavir enhanced oral formulation as part of a triple therapy for advanced AIDS patients.
Artículo
en Inglés
| IMSEAR
| ID: sea-44502
ABSTRACT
OBJECTIVE:
To compare the efficacy and safety of 1,400 mg BID and 1,200 mg TID of saquinavir soft gel given with zidovudine and lamivudine in antiretroviral-naïve, advanced AIDS patients.METHOD:
A randomized, open-label study conducted at a university hospital.RESULTS:
Forty cases were enrolled in the study, 20 cases in each group. The mean CD4 cell count was 29 cells/mm3. The mean log10 HIV-1 RNA was 5.27 copies/mL. Using an on-treatment analysis, the reduction in plasma log10HIV-1 RNA of BID and TID groups was not statistically significant at -2.44 vs -2.60 copies/mL (-0.16, 95% CI -0.63 to 0.30; p= 0.48). The mean increase in CD4 cell counts was not statistically significant at +144 and +159 cells/mm3 (11, 95% CI -75 to 97; p=0.79).CONCLUSION:
The preliminary data suggests that in antiretroviral-naïve, advanced AIDS patients, 1,400 mg BID of saquinavir soft gel given with two nucleoside analogues might be as effective as the standard 1,200 mg TID.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Femenino
/
Humanos
/
Masculino
/
ARN Viral
/
Zidovudina
/
Síndrome de Inmunodeficiencia Adquirida
/
VIH-1
/
Inhibidores de la Proteasa del VIH
/
Inhibidores de la Transcriptasa Inversa
/
Saquinavir
Tipo de estudio:
Ensayo Clínico Controlado
Idioma:
Inglés
Año:
2002
Tipo del documento:
Artículo
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