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Comparison of topical prednisolone acetate, ketorolac tromethamine and fluorometholone acetate in reducing inflammation after phacoemulsification.
Artículo en Inglés | IMSEAR | ID: sea-44651
ABSTRACT

AIMS:

To compare the efficacy and ocular adverse effects of topical prednisolone acetate, ketorolac tromethamine, and fluorometholone acetate in reducing inflammation after phacoemulsification.

METHOD:

One hundred and twenty eyes were enrolled in a prospective, investigator-masked, randomized controlled trial. Each drug was prescribed 4 times a day for 28 days. The following data were recorded weekly visual acuity, intraocular pressure, slit lamp biomicroscopy, grading of cells and flare in the anterior chamber, and ocular symptoms.

RESULTS:

The number of eyes with a minimal amount of cells in the anterior chamber in the ketorolac group was less than the prednisolone group on day 7 (1120, p = 0.008) and day 14 (2331, p = 0.015), and than fluorometholone group on day 7 (1121, p = 0.011). Intraocular pressure in the prednisolone group was higher than the ketorolac group on day 21 (14.612.2 mmHg, p = 0.016). One eye in the prednisolone group had intraocular pressure of 32 mmHg. Burning sensation was reported frequently in the ketorolac group.

CONCLUSION:

All 3 drugs were effective in reducing post-operative inflammation. The efficacy of prednisolone acetate and fluorometholone acetate was comparable. Ketorolac tromethamine showed less efficacy than corticosteroids, however, it did not induce ocular hypertension.
Asunto(s)
Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Complicaciones Posoperatorias / Valores de Referencia / Anciano / Femenino / Humanos / Masculino / Esquema de Medicación / Fluorometolona / Prednisolona / Distribución de Chi-Cuadrado Tipo de estudio: Ensayo Clínico Controlado / Estudio de etiología / Estudio observacional / Estudio pronóstico / Factores de riesgo Idioma: Inglés Año: 2003 Tipo del documento: Artículo

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Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Complicaciones Posoperatorias / Valores de Referencia / Anciano / Femenino / Humanos / Masculino / Esquema de Medicación / Fluorometolona / Prednisolona / Distribución de Chi-Cuadrado Tipo de estudio: Ensayo Clínico Controlado / Estudio de etiología / Estudio observacional / Estudio pronóstico / Factores de riesgo Idioma: Inglés Año: 2003 Tipo del documento: Artículo