Comparison of topical prednisolone acetate, ketorolac tromethamine and fluorometholone acetate in reducing inflammation after phacoemulsification.
Artículo
en Inglés
| IMSEAR
| ID: sea-44651
ABSTRACT
AIMS:
To compare the efficacy and ocular adverse effects of topical prednisolone acetate, ketorolac tromethamine, and fluorometholone acetate in reducing inflammation after phacoemulsification.METHOD:
One hundred and twenty eyes were enrolled in a prospective, investigator-masked, randomized controlled trial. Each drug was prescribed 4 times a day for 28 days. The following data were recorded weekly visual acuity, intraocular pressure, slit lamp biomicroscopy, grading of cells and flare in the anterior chamber, and ocular symptoms.RESULTS:
The number of eyes with a minimal amount of cells in the anterior chamber in the ketorolac group was less than the prednisolone group on day 7 (1120, p = 0.008) and day 14 (2331, p = 0.015), and than fluorometholone group on day 7 (1121, p = 0.011). Intraocular pressure in the prednisolone group was higher than the ketorolac group on day 21 (14.612.2 mmHg, p = 0.016). One eye in the prednisolone group had intraocular pressure of 32 mmHg. Burning sensation was reported frequently in the ketorolac group.CONCLUSION:
All 3 drugs were effective in reducing post-operative inflammation. The efficacy of prednisolone acetate and fluorometholone acetate was comparable. Ketorolac tromethamine showed less efficacy than corticosteroids, however, it did not induce ocular hypertension.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Complicaciones Posoperatorias
/
Valores de Referencia
/
Anciano
/
Femenino
/
Humanos
/
Masculino
/
Esquema de Medicación
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Fluorometolona
/
Prednisolona
/
Distribución de Chi-Cuadrado
Tipo de estudio:
Ensayo Clínico Controlado
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Estudio de etiología
/
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Idioma:
Inglés
Año:
2003
Tipo del documento:
Artículo
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