Efficacy and safety of atorvastatin 10 mg every other day in hypercholesterolemia.
Artículo
en Inglés
| IMSEAR
| ID: sea-45163
ABSTRACT
OBJECTIVES:
The authors sought to evaluate the safety and efficacy of atorvastatin administered every other day in patients with hypercholesterolemia.BACKGROUND:
Statins have efficacy in lowering cholesterol and reducing cardiovascular events but their cost is a major disadvantage. Atorvastatin is the most potent statin and has a long half-life. Therefore, atorvastatin given on alternate days may be reasonable and cost effective, particularly in hypercholesterolemia patients. METHOD ANDRESULT:
Sixty patients with hypercholesterolemia despite diet therapy were enrolled into the study. They received atorvastatin 10 mg every other day before bedtime. Duration of treatment was 8 weeks. A lipid profile was determined as baseline, at 4 weeks and again at 8 weeks. Atorvastatin every other day significantly reduced total cholesterol (TC), triglyceride (TG), and LDL-c versus baseline. The TC, TG, and LDL-c levels were lower by 23 per cent, 8 per cent, and 30 per cent. Increase in HDL-c level was not statistically significant. Three patients had drug side effects. One patient had increased serum transaminase and one patient had increased serum muscle enzyme. The other one had somnolence.CONCLUSIONS:
In hypercholesterolemia patients, atorvastatin 10 mg every other day is safe and effective in lowering TC, TG, with LDL-c and a slight increase in HDL-c.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Pirroles
/
Anciano
/
Femenino
/
Humanos
/
Masculino
/
Esquema de Medicación
/
Adulto
/
Ácidos Heptanoicos
/
Hipercolesterolemia
/
Persona de Mediana Edad
Idioma:
Inglés
Año:
2002
Tipo del documento:
Artículo
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