p53 tumor suppressor gene mutation in ovarian cancer in Thai patients.
Artículo
en Inglés
| IMSEAR
| ID: sea-45488
ABSTRACT
OBJECTIVES:
To characterize molecular mutations of p53 gene in Thai ovarian cancer and compare the mutations with their pathological and clinical findings. MATERIAL ANDMETHOD:
Direct DNA sequencing of hot spot region of p53 gene (exons 5 to 8) from 28 primary ovarian cancer tissues, 2 metastatic tumors and their paired blood samples was performed. The detected mutations were compared to the pathological and clinical findings and responsiveness to treatments after 36 months of follow-up.RESULTS:
One insertion and 4 point mutations in exon 5 of p53 gene were found in 5 out of 28 (18%) ovarian cancer patients. There was no mutation in the paired blood samples. The histological types of the detected tumors were 3 endometrioids and 2 serous cystadenocarcinomas. All 5 patients were in stage I to IV disease and showed overall 4 out of 5 (80%) complete response until 36 months after surgery followed by chemotherapy, compared to 14 out of 28 (50%) of complete response in all cases of ovarian cancer.CONCLUSION:
The authors found 5 cases of ovarian cancer patients with p53 gene mutations giving the same response to complete standard treatment as all cases. Significant factors affecting responsiveness of these patients depended more on stages, grades and histological cell types of the cancer.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Neoplasias Ováricas
/
Pronóstico
/
Femenino
/
Humanos
/
Estudios de Seguimiento
/
Genes p53
/
Mutación Puntual
/
Cistadenocarcinoma Seroso
/
Carcinoma Endometrioide
/
Estadificación de Neoplasias
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
Idioma:
Inglés
Año:
2002
Tipo del documento:
Artículo
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