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Epstein-barr nuclear antigen-1 (EBNA-1) in diffuse large B-cell lymphoma and its relationship to the bcl-2 protein.
Acta Med Indones ; 2006 Apr-Jun; 38(2): 77-80
Artículo en Inglés | IMSEAR | ID: sea-46999
ABSTRACT

AIM:

To determine EBNA-1 expression in the tissue of patients with diffuse large B-cell lymphoma and its relationship to bcl-2 expression.

METHODS:

Paraffin-embedded tissue from 24 cases of diffuse large B-cell lymphoma were stained immunohisto chemically with monoclonal antibody anti-EBNA-1 and anti-bcl-2 using Streptavidin Biotin Complex method. The bcl-2 expression was measured as negative (no staining), positive 1 (weak staining), and positive 2 (moderate to strong staining). The relationship between the immunohisto chemistry results was examined.

RESULTS:

From the 24 samples, 12 (50%) were EBNA-1 positive and 14 (58.3%) showed expression of bcl-2. Eleven of the 14 samples (90%) showed expression of bcl-2 were EBNA-1 positive, while only 3 of these samples (10%) were EBNA-1 negative. The relationship between bcl-2 expression and EBNA-1 was statistically significant (Chi square-uncorrected 11.2571, p= 0.0036).

CONCLUSION:

Our results showed that 50% of diffuse large B-cell lymphoma were EBNA-1 positive. Furthermore, EBNA-1 seemed to be correlated with bcl-2 expression.
Asunto(s)
Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Anciano / Femenino / Humanos / Masculino / Inmunohistoquímica / Estudios Transversales / Linfoma de Células B / Linfoma de Células B Grandes Difuso / Proteínas Proto-Oncogénicas c-bcl-2 / Antígenos Nucleares del Virus de Epstein-Barr Tipo de estudio: Estudio observacional / Estudio de prevalencia / Factores de riesgo Idioma: Inglés Revista: Acta Med Indones Año: 2006 Tipo del documento: Artículo

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Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Anciano / Femenino / Humanos / Masculino / Inmunohistoquímica / Estudios Transversales / Linfoma de Células B / Linfoma de Células B Grandes Difuso / Proteínas Proto-Oncogénicas c-bcl-2 / Antígenos Nucleares del Virus de Epstein-Barr Tipo de estudio: Estudio observacional / Estudio de prevalencia / Factores de riesgo Idioma: Inglés Revista: Acta Med Indones Año: 2006 Tipo del documento: Artículo