Epstein-barr nuclear antigen-1 (EBNA-1) in diffuse large B-cell lymphoma and its relationship to the bcl-2 protein.
Acta Med Indones
;
2006 Apr-Jun; 38(2): 77-80
Artículo
en Inglés
| IMSEAR
| ID: sea-46999
ABSTRACT
AIM:
To determine EBNA-1 expression in the tissue of patients with diffuse large B-cell lymphoma and its relationship to bcl-2 expression.METHODS:
Paraffin-embedded tissue from 24 cases of diffuse large B-cell lymphoma were stained immunohisto chemically with monoclonal antibody anti-EBNA-1 and anti-bcl-2 using Streptavidin Biotin Complex method. The bcl-2 expression was measured as negative (no staining), positive 1 (weak staining), and positive 2 (moderate to strong staining). The relationship between the immunohisto chemistry results was examined.RESULTS:
From the 24 samples, 12 (50%) were EBNA-1 positive and 14 (58.3%) showed expression of bcl-2. Eleven of the 14 samples (90%) showed expression of bcl-2 were EBNA-1 positive, while only 3 of these samples (10%) were EBNA-1 negative. The relationship between bcl-2 expression and EBNA-1 was statistically significant (Chi square-uncorrected 11.2571, p= 0.0036).CONCLUSION:
Our results showed that 50% of diffuse large B-cell lymphoma were EBNA-1 positive. Furthermore, EBNA-1 seemed to be correlated with bcl-2 expression.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Anciano
/
Femenino
/
Humanos
/
Masculino
/
Inmunohistoquímica
/
Estudios Transversales
/
Linfoma de Células B
/
Linfoma de Células B Grandes Difuso
/
Proteínas Proto-Oncogénicas c-bcl-2
/
Antígenos Nucleares del Virus de Epstein-Barr
Tipo de estudio:
Estudio observacional
/
Estudio de prevalencia
/
Factores de riesgo
Idioma:
Inglés
Revista:
Acta Med Indones
Año:
2006
Tipo del documento:
Artículo
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