Assessment of chlorpromazine as radiation sensitizer and protector.
Indian J Cancer
;
1996 Dec; 33(4): 195-200
Artículo
en Inglés
| IMSEAR
| ID: sea-49727
ABSTRACT
In vitro studies of chlorpromazine (CPZ) a popular anti-psychotic drug has shown radiation sensitizing effects at higher celluar concentration and protective effect at a lower concentration. The present study was designed to evaluate both sensitizing and protective effects in the treatment of advanced cancer of the cervix treated with hypofractionated external radiation and intratumoural injection of chlopromazine. Twenty patients were treated with intratumoural CPZ and radiation, while, 23 patients received radiation alone. A 52.94% complete response was noted in CPZ arm while 39.1% complete response in the control. A trend towards improved response is seen in CPZ group. Similarly patients who received CPZ showed significantly low proctitis rates.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Protectores contra Radiación
/
Fármacos Sensibilizantes a Radiaciones
/
Femenino
/
Humanos
/
Carcinoma de Células Escamosas
/
Inyecciones Intralesiones
/
Neoplasias del Cuello Uterino
/
Clorpromazina
Tipo de estudio:
Ensayo Clínico Controlado
Idioma:
Inglés
Revista:
Indian J Cancer
Año:
1996
Tipo del documento:
Artículo
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