Effect of gamma interferon on the expression of class I MHC antigens on fresh leukemic cells and their susceptibility to lysis by lymphokine activated killer cells.
Indian J Cancer
;
1994 Jun; 31(2): 96-102
Artículo
en Inglés
| IMSEAR
| ID: sea-50024
ABSTRACT
Relationship between MHC class I antigen expression on PBLs from leukemia patients and their susceptibility to lysis by LAK cells was investigated. LAK cells induced small yet significant lysis of leukemic cells. In nine out of 14 cases studied, treatment with Interferon gamma (200 U/ml for 48 hours) resulted in a decrease in the LAK susceptibility of leukemic cells. In six of these cases, there was a concomitant increase in the expression of class I MHC antigen expression. In three samples, the increase in MHC class I antigen expression was not accompanied by a decrease in LAK susceptibility. IFN treatment had no effect on the binding of leukemic cells to LAK effector cells.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Humanos
/
Células Tumorales Cultivadas
/
Linfocitos
/
Antígenos de Histocompatibilidad Clase I
/
Leucemia
/
Regulación hacia Abajo
/
Células Asesinas Activadas por Linfocinas
/
Interferón gamma
Idioma:
Inglés
Revista:
Indian J Cancer
Año:
1994
Tipo del documento:
Artículo
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