Safety and efficacy of cetuximab-chemotherapy combination in Saudi patients with metastatic colorectal cancer.
Indian J Cancer
;
2007 Apr-Jun; 44(2): 56-61
Artículo
en Inglés
| IMSEAR
| ID: sea-50168
ABSTRACT
BACKGROUND:
Cetuximab-based combination chemotherapy (CBCC) proved safe and effective as second-line strategy for metastatic colorectal cancer (mCRC). This prospective phase-II study was designed to assess the efficacy and safety of CBCC as first-, second- or third-line among Saudi patients with mCRC. MATERIALS ANDMETHODS:
Patients with mCRC were offered CBCC to assess time-to-disease progression (TTP), response rate and duration, overall survival (OS) and safety.RESULTS:
Nineteen patients were eligible and their median age was 51 years. Seven patients received CBCC as first-line and 12 as second- or third-line. Responses 11 (58%) partial responses, 5 (26%) stable disease and 3 (16%) disease progressions. The median response duration was 4.3 months [95% confidence interval (CI) 3.4-5.2 months]. The median TTP was 6.8 months (95% CI 2-13.9 months) for all 19 patients compared to 9.3 months (95% CI 3.9-14.6 months) for the seven patients who received CBCC as first-line. The median OS for the entire population was 12.3 months (95% CI could not be determined). On the other hand, while the median OS for those who received CBCC as first-line have not been reached, the median OS for those who received CBCC after failure of other salvage therapies was 12.3 months (95% CI 3.2-21.4 months). CBCC was generally tolerable. One patient had a severe hypersensitivity reaction and another fatal cardiac arrest.CONCLUSION:
CBCC is active with an acceptable safety profile. Until results from phase-III clinical trials are available, using CBCC as first-line is probably justified.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Compuestos Organoplatinos
/
Arabia Saudita
/
Infusiones Intravenosas
/
Anciano
/
Femenino
/
Humanos
/
Masculino
/
Camptotecina
/
Neoplasias Colorrectales
/
Adenocarcinoma
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Indian J Cancer
Año:
2007
Tipo del documento:
Artículo
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