Late radiation induced laryngeal oedema in the treatment of vocal cord cancer: analysis using the linear quadratic model.

ABSTRACT

The incidence of late complications for different size of dose per fraction is analysed in 208 cases with squamous cell carcinoma of the vocal cord. The series comprised 156 cases with T1 and 52 cases with T2 lesions. Radical radiotherapy was given with three different regimens having dose per fraction as 3.33, 2.5 and 2.25 Gy. There were 46 cases with persisting radiation induced laryngeal oedema. Using two different statistical methods, an alpha/beta value of 2.38 Gy of linear quadratic model was estimated for late complications of vocal cord. The analysis indicate the increased incidence of late complications with size of dose per fraction. Relevance of linear quadratic model for the prediction of late complication is demonstrated in the present study.