A comparative study of low dose weekly paclitaxel versus cisplatin with concurrent radiation in the treatment of locally advanced head and neck cancers.
Indian J Cancer
;
2009 Jan-Mar; 46(1): 50-3
Artículo
en Inglés
| IMSEAR
| ID: sea-50390
ABSTRACT
PURPOSE:
The purpose of this study was to compare low dose weekly paclitaxel versus cisplatin with concurrent radiation in locally advanced head and neck cancers. MATERIALS ANDMETHODS:
From August 2005 to July 2006, a total of 100 biopsy proven, locally advanced head and neck cancers were enrolled for the study. All the patients were stratified in two groups, study group A and control group B. Study group patients received injection Paclitaxel 20 mg/m 2 , I/V 1 hr infusion weekly for 6 weeks and control group patients received injection Cisplatin 30 mg/m 2 , I/V 2 hrs infusion weekly for 6 weeks. All patients received 66-70 Gy concurrent radiation at the rate of 2 Gy/day, 5 #/week, in 6-7 weeks by cobalt theratron phoenix - 80 teletherapy units.RESULT:
Complete response achieved in 73% of patients in study group and 64% of patients in control group. There was no statistically significant difference observed between the study group and the control group (chi2 = 1.167, df = 1, level of significance 0.05). On 3-10 months of follow-up 59% of patients in the study group and 42% of patients in the control group are alive and disease free. Local toxicities including mucositis, dysphasia and skin reactions were more in the study group but tolerable.CONCLUSION:
Efficacy of paclitaxel in low dose weekly schedule is comparable to cisplatin in locally advanced head and neck squamous cell carcinoma. Further analysis and follow-up are needed to evaluate if this benefit will translate into prolonged survival.
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IMSEAR (Asia Sudoriental)
Asunto principal:
Pronóstico
/
Anciano
/
Femenino
/
Humanos
/
Masculino
/
Protocolos de Quimioterapia Combinada Antineoplásica
/
Tasa de Supervivencia
/
Estudios Retrospectivos
/
Cisplatino
/
Resultado del Tratamiento
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
Idioma:
Inglés
Revista:
Indian J Cancer
Año:
2009
Tipo del documento:
Artículo
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