Treatment evaluation, follow-up and familial screening of medullary thyroid carcinoma by highly specific calcitonin measurements.
Indian J Cancer
;
2006 Apr-Jun; 43(2): 75-9
Artículo
en Inglés
| IMSEAR
| ID: sea-50748
ABSTRACT
BACKGROUND:
Calcitonin is the most sensitive and specific marker for medullary thyroid carcinoma (MTC).AIMS:
The aim of this study was to emphasize the role and the limits of plasma basal calcitonin (bCT) measurement in the management of Moroccan MTC patients and their relatives. SETTINGS ANDDESIGN:
This is a retrospective study on 6 MTC patients referred to our institute from January 1996 to December 2004. MATERIALS ANDMETHODS:
Serum bCT levels were measured in 36 individuals comprising six known MTC cases, 18 relatives and 12 healthy volunteers, using two-sites immunoradiometric assay method. Five of MTC patients have been followed from 12 to 96 months after surgery. STATISTICAL ANALYSIS USED Calculations were performed using SPSS 10.0 program. Data comparison was done by Student's t -test.RESULTS:
The circulating preoperative bCT concentrations were elevated for all MTC patients (range, 44,8 -2055 pg/ml, normal <10). Recent postoperative bCT determinations varied from 24.4 to 1972 pg/ml in four patients. In one patient, the bCT value decreased to an undetectable level during a follow-up of 12 months. The mean bCT level of relatives was 4.90 +/- 3.54 pg/ml; two patients had slightly elevated bCT. Five (42%) healthy volunteers had undetectable bCT levels and all had less than 10 pg/ml; the mean bCT value was 3.06 +/- 2.51 pg/ml.CONCLUSIONS:
Routine plasma bCT measurement still has an important place in the preoperative diagnosis and follow-up treatment of MTC.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Anciano
/
Femenino
/
Humanos
/
Masculino
/
Calcitonina
/
Neoplasias de la Tiroides
/
Biomarcadores de Tumor
/
Ensayo Inmunorradiométrico
/
Tamizaje Masivo
/
Estudios Retrospectivos
Tipo de estudio:
Estudio diagnóstico
/
Estudio observacional
/
Estudio pronóstico
/
Estudio de tamizaje
Idioma:
Inglés
Revista:
Indian J Cancer
Año:
2006
Tipo del documento:
Artículo
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