Expression of Toll-like receptors 2 and 4 in gingivitis and chronic periodontitis.
Artículo
en Inglés
| IMSEAR
| ID: sea-51696
ABSTRACT
Periodontal disease is the major cause of adult tooth loss and is commonly characterized by a chronic inflammation caused by infection by oral bacteria. Members of Toll-like receptor (TLR) family recognize conserved microbial structures, such as bacterial lipopolysaccharides, and activate signaling pathways that result in immune responses against microbial infections. The aim of the present study was to assess the mRNA expression of TLR-2 and TLR-4 in gingivitis and chronic periodontitis. Gingival tissue samples were collected from patients with chronic periodontitis, gingivitis, and healthy controls. Total RNA was extracted and RT-PCR was done for TLR-2 and TLR-4. The results showed that TLR-2 was significantly increased in gingivitis compared to TLR-4 expression and decreased in chronic periodontitis.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Periodontitis
/
Humanos
/
ARN Mensajero
/
Regulación de la Expresión Génica
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Enfermedad Crónica
/
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa
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Placa Dental
/
Receptor Toll-Like 2
/
Receptor Toll-Like 4
/
Encía
Idioma:
Inglés
Año:
2006
Tipo del documento:
Artículo
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