The diagnostic and prognostic implications of silver-binding nucleolar organizer regions in periodontal lesions.
Artículo
en Inglés
| IMSEAR
| ID: sea-51729
ABSTRACT
BACKGROUND:
The periodontal lesions with cellular proliferation can be assessed by various methods. One of the most recent methods to determine the proliferative activity is silver-staining nucleolar organizer region (AgNOR) staining. The purpose of the present study was to evaluate, if AgNOR count can act as a proliferative marker and can aid in the diagnosis and prognosis of periodontal lesions. MATERIALS ANDMETHODS:
For this study, subjects with healthy gingival status, non-neoplastic lesions, neoplastic lesions, and plaque-induced gingivitis were included. Following the provisional diagnosis of clinical entity, biopsies were taken from the respective selected sites for histopathological diagnosis. In plaque-induced gingivitis cases, a second biopsy was taken from the selected sites 3 weeks following scaling. After histological confirmation, one more section was prepared, which was subjected to AgNOR staining, and AgNOR numbers were counted by individual and cluster counts and statistically analyzed.RESULTS:
Results showed the highest AgNOR count in neoplastic lesions. Non-neoplastic lesions showed a higher AgNOR count as compared to clinically healthy gingiva. Plaque-induced gingivitis showed a considerable reduction in AgNOR count after treatment.CONCLUSION:
Results of this study confirmed that AgNOR count reflects the cellular proliferation and has a limited diagnostic value. However, the prognostic value of AgNOR for periodontal lesions is dependable.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Enfermedades Periodontales
/
Pronóstico
/
Femenino
/
Humanos
/
Masculino
/
Neoplasias Gingivales
/
Biomarcadores
/
Análisis de Varianza
/
Adolescente
/
Tinción con Nitrato de Plata
Tipo de estudio:
Estudio pronóstico
Idioma:
Inglés
Año:
2008
Tipo del documento:
Artículo
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