Premature ovarian failure due to cyclophosphamide: a report of four cases in dermatology practice.
Indian J Dermatol Venereol Leprol
;
2008 Mar-Apr; 74(2): 128-32
Artículo
en Inglés
| IMSEAR
| ID: sea-51946
ABSTRACT
Immunosuppressant drugs like cyclophosphamide are used in the treatment of a variety of skin disorders. Though it is a very useful drug, it has some serious side-effects. Prolonged amenorrhea due to premature ovarian failure leading to infertility is one of the serious side-effects of cyclophosphamide. Four cases of cyclophosphamide-induced premature ovarian failure are presented. Two patients of scleroderma, one patient of pemphigus and one patient of hypersensitivity vasculitis developed amenorrhea due to premature ovarian failure leading to infertility after receiving cyclophosphamide 50 mg o.d. for eight months to one year. The ages of these patients ranged from 28-38 years. All these patients had good improvement of their disease with cyclophosphamide. These patients did not experience any other side-effects and their routine blood and urine tests were normal. There were no spontaneous menses during the follow-up period of one to two years. Because of the serious risk of developing premature ovarian failure, cyclophosphamide should be avoided in those patients where the family is not complete.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Femenino
/
Humanos
/
Insuficiencia Ovárica Primaria
/
Adulto
/
Ciclofosfamida
/
Dermatología
Idioma:
Inglés
Revista:
Indian J Dermatol Venereol Leprol
Año:
2008
Tipo del documento:
Artículo
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